Effectiveness of the Combined Antipsychotic and Brain Synchronization Therapy in Patients with First Episode Psychosis


Ain Shams University, Neuropsychiatry, Cairo, Egypt


Background: Brain Synchronization Therapy (BST) is widely used in the management of resistant schizophrenia. Meanwhile, there is less research regarding efficacy of BST in first episode psychosis.

Aim: This study aimed to assess the effectiveness of BST combined with antipsychotic medications in patients with first episode psychosis.

Method: This cross sectional prospective study was conducted between June 2015 to December 2015, on 50 patients with first episode psychosis, their age ranges from 18 to 40 years. The patients received their treatment in the form of antipsychotic medications and 3 sessions of BST every week with maximum 12 sessions. Clinical outcomes were measured using Positive and Negative Syndrome Scale (PANSS), Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression (CGI) at admission and discharge.

Results: The results showed statistically significant reduction in PANSS score (127.51 SD 12.66 on admission to 68.39 SD 10.92 on discharge with 46.26% percentage of change), BPRS score (72.65 SD 8.95 on admission reduced to 34.41 SD 6.5 with 52.40% percentage of change) and CGI score (5.5 on admission reduced to 1.5 on discharge with 71.14% percentage of change).

Conclusion: The combination of BST and antipsychotic medication is an effective strategy in the acute treatment of first episode of psychosis, adding BST to medications seemed to be an acceleration of treatment response which could be of cost benefit importance in developing countries.