PS33: ANXIETY SENSITIVITY LINKS WITH CORONARY HEART DISEASE AND INFLAMMATORY MARKERS: INTERLEUKIN 6 AND INTERLEUKIN 8

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AUTHORS
Indraja Velickiene1, Alvydas Navickas1, Zaneta Petrulioniene2, Rima Viliūnienė1

1Vilnius University Medical Faculty Psychiatric Clinic, Lithuania
2Vilnius University Medical Faculty Clinic of Cardiac and Vascular Diseases, Vilnius, Lithuania

ABSTRACT DESCRIPTION

Background: The aim of the study was to investigate and compare anxiety sensitivity among participants diagnosed with panic disorder, general anxiety disorder and diagnosed with coronary heart disease. IL-6 and IL-8 were measured for male participants to assess an inflammation role in anxiety and the results compared with ASI-R-36 scores and between the participant groups (diagnosed with coronary heart disease and anxiety disorders).

Method: 232 participants were investigated, 119 women and 113 men. The participants were divided into three groups: (i) a control (healthy) group, (ii) patients diagnosed with anxiety disorders and (iii) patients diagnosed with coronary heart disease. The inflammatory markers, such as the levels of Interleukins 6 and 8 were measured in male participants.

Results: The ASI-36-R score in the anxiety group was 62.70, while in the control group the score was 34.16 (SN = 23.44). For participants diagnosed with coronary heart disease no increase in the ASI-R-36 scores compared with the control group, p=0.005. The subscale score of fear of cardiovascular symptoms (1.55 and 1.81, p=0.306) between participants diagnosed with anxiety disorder and coronary heart disease groups showed expressed fear of cardiovascular symptoms in both groups. Women were more likely to have higher scores in the ASI-R-36 than men. Step-wise linear regression showed that the participants with moderate and intense physical activity had lower ASI-R-36 scores than those with low physical activity. IL-8 levels were increased in those with an increased ASI-R-36 score and the subscale for fear of loss of cognitive control was associated with an increase in IL-8.

Conclusions: Anxiety Sensitivity was higher for participants diagnosed with anxiety disorders, but fear of cardiovascular symptoms was expressed in both groups. The increased IL-8 levels were measured for participants diagnosed with anxiety. The ASI-R-36 score was lower in the groups with moderate and high physical activity.

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